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Final steps in escort aptamer preparing involve synthetic changes of the truncated aptamer

Final steps in escort aptamer preparing involve synthetic changes of the truncated aptamer Further nuclease stabilization is achieved by substitution of 2?-OCHstep 3 for 2?-OH at purine positions. As the 2?-OCH3 moiety is not compatible with current SELEX process enzymes, this alteration must occur during chemical synthesis following evolution of a specific aptamer sequence. Generally, … Read more